[32] reported statistically significant improvement in mechanical stimulated DH with Pro-argin immediately after topical application relative to 8% strontium Acetate in 2016. Product Benefits. Not all desensitizing toothpastes perform equally well. To alleviate their tooth sensitivity problem, by using Colgate Sensitive Pro-Relief will give them lasting relief and they can drink ice water freely. Participants were asked to pick up the envelope from the box. Dentifrices were removed carefully after one minute of undisturbed application by rinsing the air lightly with an air syringe, and the subject was asked to spit. Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. Customers also search toothpaste colgate sensitive colgate enamel colgate pro relief colgate pain relief Schiff T, Delgado E, Zhang Y, Cummins D, DeVizio W, Mateo L. Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. Pessoa, Loretto et al. Tel: +381 (0)21 452-910, +381 (0)21 420-758. Colgate Sensitive Pro-Relief Multi Protection Toothpaste provides clinically proven instant and lasting relief for sensitive teeth For instant relief, apply directly to each sensitive tooth with finger tip and gently massage for 1 minute, up to twice daily Pro-Argin technology helps to seal and repair . The secondary analysis population could be described as 20 participants per treatment group out of 35 enrolled in the six-week trial who responded to mechanical and water jet stimuli on VAS with scores of4 as secondary outcome measures. For more great Dental Care products like toothpaste and mouthwash, continue browsing online and buy in-store at B&M. Colgate Sensitive Instant Relief Toothpaste 75ml Product code: 326795 2.49 Subject to availability - visit your nearest store Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This toothpaste really does not help at all with symptoms of sensitive teeth. Colgate Tandpasta Sensitive Instant Relief Whitening. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste with Pro-Argin Technology and Zinc. For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. PubMedGoogle Scholar. [28] reporting the immediate effect of 8% strontium acetate in alleviating clinical symptoms of DH with clinically and statistically significant (<0.001) measures relative to baseline [26]. Colgate Sensitive Instant Relief Enamel Toothpaste with Pro-Argin technology to help seal and repair the sensitive areas of teeth. The benefits are backed by over a decade of clinical research, summarized as follows. Dentin hypersensitivity is characterized by a short, sharp pain arising from open dentin tubules in exposed dentin in response to external stimuli, which cannot be attributed to any other defect or disease. We observed the varying treatment response at different efficacy intervals that could be due to the varying degree of patient's response to pain-provoking stimuli in DH. p values of<0.05 were considered as statistically significant. Am J Dent. Register now and gain access to: 8 hours ECPD Product samples Patient materials Register here * For instant relief, apply directly to the sensitive tooth with finger tip and gently massage for 1 minute. With regular use, it creates a long-lasting protective barrier that acts as a seal against sensitivity. These ingredients resulted in rapid fluorapatite crystallisation at exposed tubular ends of dentin [12]. Significantly greater sensitivity reduction with twice - daily brushing compared to control toothpaste with potassium ions. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. The strength of this study was that participants were randomised into four treatment groups to generalise the results for the population [32]. Purchased in August 2019 at Coles for $5. Treatments provided to the patients were OTC dentifrices marketed with the claim of immediate pain relief in DH. Ingredients *Calcium carbonate *Water Paired sample T-test was used to compute mean scores to observe change relative to baseline at each time point. Akber A, Ali NS, Shabbir S, Wahid U, Farooqui WA. Another study by Hines et al. However, strontium acetate can potentially obliterate dentinal tubules by replacing the calcium ions of hydroxyapatite crystal lattice structure withstrontium ions along with its nerve depolarisation treat DH [7]. Mode of action studies on a new desensitizing dentifrice containing 8.0% arginine, a high cleaning calcium carbonate system and 1450 ppm fluoride. HOW DOES Colgate SENSITIVE INSTANT Relief Repair & Prevent WORK? 2019;88:103170. The comparative evaluation was done for the clinical efficacy of Pro-argin and 8% strontium acetate, and a statistically significant (p>0.05) difference was not found between these two formulations in the current study. Colgate Sensitive Instant Relief Multiprotection Toothpaste gives you clinically proven lasting relief from sensitivity for 8 weeks when you use it twice a day. 3Intervention for Group C denotes Sensodyne Rapid Action. Frequency of dentin hypersensitivity: a cross-sectional study. Dentine hypersensitivity (DH) is a chronic condition with acute, transient pain in non-carious teeth that originates in response to thermal stimuli such as hot or cold, chemicals like acidic or sweet or salt, and mechanical stimuli due to exposure to dentinal tubules without any apparent clinical disease [1]. Colgate Sensitive PRO-Relief Provides clinically proven, everyday protection from painful sensitivity. Colgate Sensitive Pro-Relief (Toothpaste): 1.9 out of 5 stars from 91 genuine reviews on Australia's largest opinion site ProductReview.com.au. Arginine, Calcium Carbonate, Aqua, Sorbitol, Aroma, Poloxamer 407, Sodium Monofluorophosphate, Cocamidopropyl betaine, Zinc oxide, Benzyl Alcohol, Cellulose Gum, Zinc Citrate, Sodium Bicarbonate, Tetrasodium Pyrophosphate, Xantham Gum, Sodium Saccharin, Sucralose, Limonene, CL77891, 1. Pro-Argin technology is occlusive. It has stannous fluoride as an active ingredient. For lasting relief and gum protection, apply twice daily using a sensitive toothbrush, making sure to brush all surfaces of teeth including sensitive areas. Two double-blind randomized clinical studies by Nathoo et al. The sealed envelope contained details of unique subject numbers assigned individually in ascending order, group titles, and treatment codes and was placed in the box. Pessoa OF, Loretto SC, Maia LC. If symptoms persist, talk to your healthcare professional. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Use regularly to enjoy long-lasting relief from sensitivity*. [22] reporting the instant relief from DH by 44.1% with Pro-argin on SCASS. All rights reserved. Another study by Vu Pham and Anh Nguyen reported clinical improvement in DH by 38.9% on SCASS and 40.2% on VAS for mechanical stimulated DH immediately after application of Pro-argin [25]. Follow the directions for use. Nathoo S, Delgado E, Zhang YP, DeVizio W, Cummins D, Mateo LR: Comparing the efficacy in providing instant relief of dentine hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride and to a control toothpaste with 1450 ppm fluoride: A three-day clinical study in New Jersey, USA. They reported more clinical efficacy with BioMin than Pro-argin reduction in air-blast stimulated DH on VAS after one month [39]. 2019;81:16. Made by one of the best-known oral care companies in Australia, it has been clinically proven to provide both instantaneous and lasting relief from sensitivity, whilst also: Fighting cavities. Therefore, the first null hypothesis was that mean scores for pain due to DH among different treatment groups for immediate relief remain. Can be used after the Colgate Sensitive Pro-Relief Desensitizing Paste. Identifier NCT 04249336. Colgate Professional has resources to help your patients understand what causes enamel erosion and how to avoid falling into those traps. It revealed an immediate improvement with strontium acetate more than Pro-argin on SCASS. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Last updated on May 11, 2021. https://clinicaltrials.gov/ct2/show/NCT04249336. IRB-1351/DUHS/Approval/2019/184. There is no problem with every day and prolonged use. Compend Contin Educ Dent. 2017;2017:2. All the treatment groups subjected to testing in the present study revealed a considerable clinically significant symptomatic reduction in DH relative to the pre-treatment condition that was also statistically significant. Mintsmak. 7 Ipsos, UK Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2 weeks trial, 192 respondents, 2016. This toothpaste prevents sensitivity coming back by building a protective barrier that acts like . All participants were instructed to dry the tooth surface with the cotton ball and apply a paste of about half-inch length on the dried surface for one minute, then brush the teeth twice daily after breakfast and before sleep as per directions demonstratedon the study model. [41] was performed in 2017 and reported inappropriate statistical methodologies related to the normal distribution of data and equality of variances, along with lacking information in 77.1% of the thirty-five randomised trials on DH management. Mockdeci H, Polonini H, Martins I, Granato A-P, Raposo N. Evaluation of ex vivo effectiveness of commercial desensitizing dentifrices. Many patients tolerate the pain of sensitive teeth because theyre unaware of simple but highly effective answers like Pro-Argin technology. Our study included an Asian population, and most of the published literature was associated with the Caucasian population. Colgate uses need to categorize. Based on the outcomes of previous systematic reviews and meta-analysis, the rationale of the present study was to substantiate the claim of immediate pain relief after one-minute application in DH by non-invasive surface application of OTC dentifrices containing Pro-arginin Colgate Sensitive Pro-Relief, and 8% strontium acetate in Sensodyne Rapid Action and other objective was the comparative evaluation of the clinical efficacy of three technologies, BAG-based FCPS in BioMinR F, Pro-argin, and 8% strontium acetate at efficacy intervals of day three, week two, four and six for sustained inhibition of painful stimulus provoking DH as all three are dentinal tubular occluding dentifrices. Dentine tubule occlusion by novel bioactive glass-based toothpastes. Plugging the channels that lead to sensitive tooth nerves to help relieve sensitivity. 2023 BioMed Central Ltd unless otherwise stated. J Evid Based Dent Pract. Am J Dent. Follow the directions for use. We provided oral hygiene instructions and ways of relieving their pain from DH to improve their quality of life. Therefore, it was considered to be rejected at a p valueof 0.05. [8] that demonstrated the inherent ability of chemical interaction between arginine and type 1 collagen molecules in the salivary alkaline PH, thus resulting in endogenous calcium phosphate deposition on exposed dentinal tubules. These participants were randomized equally by the principal investigator into four entitled treatment arms using computer-generated random sequence numbers, and treatments were allocated randomly using sequentially numbered, opaque, sealed, and stapled envelopes (SNOSE). The Sensitive Pro-Relief Multi-Protection toothpaste by Colgate thoroughly cleans your teeth, while providing you with relief from sensitive tooth pain. Colgate Sensitive Pro Relief Instant Relief, Plugging the channels that lead to sensitive tooth nerves to help relieve sensitivity. Apotekets varuid 29483 Varunummer 207000 Kategori Tandkrm, Ilningar i tnderna Varumrke Elsevier; 2015. p. 3344. J Clin Dent. 6 Ipsos, Romania Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2-week trial, 545 respondents, 2015. Layer T, Hughes N. Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity. Colgate SENSITIVE INSTANT Relief tannkrem med Pro-Argin teknologi gir umiddelbar* og langvarig smertelindring av ising i tennene. https://doi.org/10.17352/2394-8418.00003. J Clin Periodontol 42 S17 (2015) 4. A meta-analysis by Grnberg et al. Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. However, there is a substantial possibility that these fluoridated dentifrices can reduce DH. A meta-analysis by Matranga et al. In addition, they were responding to air-blast stimulus on the Schiff cold air sensitivity scale (SCASS) with scores2 [22]. Yes, Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste should be used for twice daily toothbrushing to provide ongoing relief from the pain of sensitive teeth. Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. Innehller slipmedel med ltt polerande effekt p flckar samt fluor som minskar risken fr karies. J Evid Based Dent Pract. 2019;40(10):6537 (quiz 8). These findings were similar to a previous study conducted by Schiff et al. In addition, one-Way ANOVA with Post Hoc Tukey for pair-wise comparison was used to compare treatment groups computing percent change from baseline with formula (post-application mean scores-baseline mean scores/baseline mean scores). I want to acknowledge the administrative faculty and staff assistants in the Department of Periodontology for facilitation in data collection. It was found statistically significant relative to control on all clinical parameters of the SCASS and VAS. According to Holland's guidelines of conducting a trial for managing DH, two diagnostic tools are sufficient for quantitative assessment of the clinical efficacy of desensitisers. Colgate Total with stannous fluoride also offers more benefits than ever before, including sensitivity relief, improved enamel strength* and odor neutralization* (*based on in vitro studies).Colgate Total Advanced Whitening is a tooth whitening toothpaste that provides stain removal and prevention. 2010;21(2):568. Part of Department of Oral Biology, Dr. Ishrat-Ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Dow University of Health Sciences, Karachi, Pakistan, Department of Oral Biology, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan, Department of Research, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan, You can also search for this author in Clinically proven Instant and lasting Sensitivity relief*. Colgate Sensitive Pro-Relief r en tandkrm som ger omedelbar och varaktig lindring mot ilningar i tnderna. We found more change in pain scores of VAS used for mechanical stimuli with Pro-argin than FCPS as shown in Table 5 that could be relatable with a randomised controlled trial of FCPS and arginine based desensitizers reporting better treatment response of arginine than FCPS in the cold stimulated DH after two weeks to one month, subsequently [40]. Pro-Argin technology provides instant* and long-lasting, Oral Care Products | Colgate Professional. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Poster #3406, July 2018 IADR. Plain bi-carb soda and coconut butter do a far better job at cleaning and desensitising. By using this website, you agree to our Treatment difference between FCPS, Pro-argin, and 8% strontium acetate was not statistically significant with a p>0.05 for sustained pain relief in DH. Mantzourani M, Sharma D. Dentine sensitivity: past, present and future. Based on the synthesis of study results, we can conclude that Pro-argin in Colgate Sensitive Pro-relief and 8% strontium acetate in Sensodyne Rapid Action both are effective for pain relief in one minute after application in DH with better immediate treatment response of Pro-argin than strontium acetate. Cookies policy. The first post-treatment measure of SCASS and VAS scores was obtained immediately after removing dentifrices from teeth. It remains a prevalent global disease with two different treatment modalities of home-care desensitisation with the over-the-counter (OTC) desensitisers such as potassium, With regular use, it reduces teeth sensitivity and helps to strengthen gums and prevent gum recession. Provided by the Springer Nature SharedIt content-sharing initiative. The study's primary objective was to investigate pain relief in one minute with Pro-argin and strontium acetate in DH measured on SCASS as a primary outcome measure and VAS as a secondary outcome measure. in 2018 [17]. The datasets analysed during the current study are available from the corresponding author on reasonable request. It uses an 8% arginine and calcium carbonate formulation to quickly seal the open dentin tubules, replicating and enhancing the natural mechanism of hypersensitivity relief. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth**. They explored greater tubular occlusion potential and more acid resistance of Pro-argin in comparison to FCPS after subsequent seven days of application on dentinal discs [38]. Docimo R, Montesani L, Maturo P, Costacurta M, Bartolino M, DeVizio W, Zhang YP, Cummins D, Dibart S, Mateo LR: Comparing the Efficacy in Reducing Dentine Hypersensitivity of a New Toothpaste Containing 8.0% Arginine, Calcium Carbonate, and 1450 ppm Fluoride to a Commercial Sensitive Toothpaste Containing 2% Potassium Ion: An Eight-Week Clinical Study in Rome, Italy. Explore the videos and articles found on this page to assist in better oral care. Dentine hypersensitivity. The limitation of our study is that fluoridated dentifrice was used as a control which, although regarded as not possessing any desensitising effects. Moreover, FCPS as a new bioactive material revealed promising potency of sustainable management of DH in a previously conducted trial by Ashwini et al. Hines D: Poster #0742 March 2018 AADR. 2009;22:3A-7A. 2010;21(2):428. 2013;41:S317. Further, it leaves a durable, mineral-enriched layer on the exposed dentin to help protect against future dentin hypersensitivity. Besides, these findings of the current study could be related to previously conducted clinical trials indicating the better clinical effectiveness of Pro-argin than strontium acetate against air-blast and tactile stimulus after three days and one week of application [30, 31]. 2019;46(12):11216. Favaro Zeola L, Soares PV, Cunha-Cruz J. It contains clinically proven Pro-Argin technology which provides instant and lasting sensitivity relief. The makers of Colgate Sensitive Pro-Relief and its rival, Sensodyne Rapid Relief, have been dobbing each other into the health regulator over advertising claims that the toothpastes give users "instant" relief to pain from sensitive teeth. If the enamel is too thin, has tiny tubules that reveal the underlying dentin, or is worn down in some places. Lasting relief with 2x daily continued brushing. Tandkrmen innehller zink fr att strka tandkttet och frhindra att tandkttet drar sig tillbaka, vilket r en av de vanligaste orsakerna till att . 5 Hines D et al. Plus it has the freshness you trust from Colgate! This binds to the negatively charged dentine surface like a magnet. These dentifrices were extracted in a plain tube by the dental assistant from commercial packing and labelled with treatment codes to keep the principal investigator and participants blinded at the time of treatment assignment. It also strengthens tooth enamel by helping rebuild weak spots. Trials. Dentifrices-containing Pro-argin showed a significant reduction in DH with mean scores of (3.052.17) followed by strontium acetate (3.751.97) followed by FCPS (5.301.83) one minute after application. Shiau HJ. Madurai: Best Dental Science College; 2020. Lai et al. Hu ML, Zheng G, Lin H, Yang M, Zhang YD, Han JM. found the clinical efficacy of Pro-argin better than strontium acetate for mechanical and air-blast stimulated DH on VAS and SCASS in follow-up periods of one minute, three days, two, four and eight weeks in a systematic review in 2015. With its unique Pro-Argin technology, this sensitive toothpaste will give you instant* relief from sensitivity as it helps to seal and repair the sensitive areas of your teeth (with continued use twice a day). Colgate Sensitive Pro-Relief It works by plugging the channels to block tooth sensitivity and with regular use. WAF has contributed to revising the manuscript critically and contributed to statistical analyses. Indian J Dent Sci. The relief from sensitivity offered by Colgate Sensitive Pro Relief is proven to last. Colgate Sensitive Pro Relief Multi Protection, offering all of the above benefits in one convenient formula. The impact of FCPS, Pro-argin, and strontium acetate-based treatments of DH on the oral health-related quality of life together with the difference in the effectiveness of treatments were assessed individually rather than in groups in the current six-week trial. Therefore, the current study outcomes were analysed by parametric and non-parametric statistical tests after assessing the normal distribution of data and equality of variances with Shapiro Wilk statistics. 1Intervention for Group A denotes BioMin F. 2Intervention for Group B denotes Colgate Sensitive Pro relief. Dentin hypersensitivity can have significant detrimental effects on your patients wellbeing and quality of life. With regular use, the Pro-Argin formula builds a long-lasting protective barrier that acts like a seal against sensitivity. 1,2 https://doi.org/10.1186/s12903-021-01864-x, DOI: https://doi.org/10.1186/s12903-021-01864-x. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste contains Sodium Fluoride (1450ppmF) the recommended fluoride level for effective caries prevention.4. Size: 75ml (Approx.) Colgate Sensitive PRO-Relief provides you relief from sudden shocks of pain and long-term sensitivity with regular use. The permanent management of DH is being investigated with the remineralisation potential of bioactive agents in dentinal tubules. 1 Nathoo et al. da Cruz LPD, Hill RG, Chen X, Gillam DG. PREVENTS SENSITIVITY COMING BACK: Sealed channels protect against pain for instant relief, and with regular use provide lasting protection to prevent sensitivity from . A toothbrushing demonstration model from Nissin Company specification [PE-ORT002] was used to explain to the study participants about applying OTC dentifrices for one minute with the participant's finger. Am J Dent. While 8% strontium acetate showed a greater clinical reduction in water jet stimulated DH on VAS than Pro-argin at all efficacy intervals, as demonstrated in Table 6. Cite this article. While FCPS in BioMin F can be the best possible treatment option for long-term management of DH in the form of OTC dentifrices. The price for Colgate Sensitive Pro-Relief is set at RM12.80 to avoid being categorized at RM13.00. Colgate Sensitive Pro-Relief Original Toothpaste This toothpaste gives you the freedom to forget about tooth sensitivity. For lsting relief, apply to a gentle toothbrush making sure to brush all . Pashley D. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. 2018. Product Details For instant relief, apply directly to the sensitive tooth with finger tip, and massage gently for 1 minute, once a week or less frequently. Docimo et al. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste delivers instant* and long-lasting sensitivity relief plus gum protection. These commercially available tooth paste are one n the same thing.Both says they work in reducing the tooth senstivity due to cold intake.These may help olny during the early stages but when there is sensation to both cold and hot drinks and pain, you need to visit a dentist. Grading of Recommendations, Assessment, Development and Evaluations. After six weeks, FCPS-based dentifrices showed greater clinical efficacy with mean scores (1.801.73) than other treatment arms for waterjet stimulated DH. Gentle whitening formula. Blocks the pain of sensitive teeth. Last updated on May 11, 2021. Balevi B. Clinically proven lasting relief for 8 weeks. Martins C, Firmino R, Riva J, Ge L, Carrasco-Labra A, Brignardello-Petersen R, et al. They don't. 2018;2018:110. ^Vs novamin/sodium fluoride technology and stannous fluoride/sodium fluoride technology (p<0.05). Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste for the daily oral care of patients with dentine hypersensitivity and gum problems. J Clin Dent 20 (2009), special issue 123-130, 2. This clinical trial was not funded by any agency in public, commercial or not-for-profit sectors. Product Details Characteristics and Benefits Characteristics: Unique Pro-Argin TM/MC technology based on natural process of tubule occlusion Therefore, this trial was planned to investigate the clinical efficacy of Pro-argin and strontium acetate for immediate pain relief in DH after one minute of topical application to fill the research gap associated with limited published evidence and risk of bias in selection, performance, attrition, and reporting as predicted by Pessoa et al. A head-to-head comparative evaluation of these most effective bioactive agents, such as arginine and BAG-based desensitisers, was suggested by Martins et al. Colgate Sensitive Pro Relief offers a solution that is clinically proven to relieve sensitivity pain. Ingredients *Calcium carbonate *Water For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. Exclusive Pro-Argin formula. Work with Colgate Professional to help provide better oral care to your patients. Mahmoodi B, Wood R, Cook R. Protection and acid resistivity of bioactive-glasses, arginine and calcium silicate. 2017;62(2):18691. 75 ml. A randomised clinical trial on the efficacy of 5% fluorocalcium phosphosilicate-containing novel bioactive glass toothpaste. The prevalence of DH was found to vary from about 5 to 62% owing to the use of different diagnostic and measuring tools and age groups in the published literature, with the best average estimate of 34% worldwide [3]. It is clinically proven for instant and lasting Sensitivity relief* How does it work? Published literature [16, 31, 43] has determined that all previous trials on treating DH were conducted on smaller samples, which might have prevented the results from being extrapolated on the general population. We were using the PAS version.11, two independent sample t-test with 95% confidence interval and 80% power of test, meanSD of air blast stimulus test score of test group 1.860.41 and control group 2.220.41 two weeks after baseline test score, the calculated sample size was 22 [21] which was raised to 35 including five as drop out for each group (Fig.
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