Arjmandi BH. Common interactions include arthralgia among females and diarrhoea among males. Urology 2001;58:47-52. Flaxseed reduces some risk factors of cardiovascular disease. View abstract. 2005 - 2023 WebMD LLC. Eur J Clin Nutr 2007;61:1423-8. J Womens Health (Larchmt) 2008;17:355-66. The phase IV clinical study analyzes what interactions people who take Flax seed and Aspirin have. Accessed Sept. 27, 2017. Cancer Epidemiol Biomarkers Prev 2000;9:335-8. Nutr Cancer 2007;58:162-70. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If we combine this information with your protected Appl Physiol Nutr Metab 2009;34:89-98. Diabetes drugs. Arerugi. When considering the use of herbal supplements, seek the advice of your doctor. Thompson LU, Rickard SE, Orcheson LJ, Seidl MM. Savas BB, Alparslan GB, Korkmaz C. Effect of flaxseed poultice compress application on pain and hand functions of patients with hand osteoarthritis. Flax can affect blood-clotting and may increase your risk of bleeding. 2016 Jun;35(3):615-25. (2008). Serraino M, Thompson LU. Avoid using flax together with other herbal/health supplements that can lower blood sugar, such as alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others. Sardines - bone loss, joint pain. Flaxseed oil is an oil made from pressed, ground flaxseeds. Dodin S, Lemay A, Jacques H, et al. Therefore, using flaxseed oil to relieve your bowels will not have the same effect as using flax seeds. Int J Cancer 2006;119:2376-81. View abstract. We comply with the HONcode standard for trustworthy health information. Pan A, Demark-Wahnefried W, Ye X, et al. Rose DP. Beta . Furthermore, some blood thinners, NSAID pain killers, hormone treatments, and certain medications for blood pressure, cholesterol, and diabetes may interact with flaxseed oil and flaxseed. View abstract. privacy practices. Store at room temperature away from moisture and heat. National Center for Complementary and Integrative Health. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023 . Though your body can make many types of fat on its own, such as cholesterol, omega-3 fatty acids are essential and must be supplied from outside sources. Its important to be cautious when using flaxseed oil, as there are several risks and side effects. Flaxseed - More Interactions. View abstract. Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. However, NCCIH says the evidence that flaxseed oil has health benefits is conflicting, and more research is needed before claims can be made. Bierenbaum ML, Reichstein R, Watkins TR. Mohammadi-Sartang M, Mazloom Z, Raeisi-Dehkordi H, Barati-Bodaji R, Bellisimo N, Totosy de Zepetnek JO. Gholami Z, Akhlaghi M. The effect of flaxseed on physical and mental fatigue in children and adolescents with overweight/obesity: a randomised controlled trial. A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. https://naturalmedicines.therapeuticresearch.com. This article explores 9 science-backed benefits of eating flaxseed. An effective alternative or complement to medications in managing hypertension is through lifestyle modifications. You may report side effects to FDA at 1-800-FDA-1088. Flaxseed oil contains ALA, which your body primarily uses as a source of energy, according to Harvard T.H. Taking flaxseed along with medications that also slow blood clotting might increase the risk of bruising and bleeding. There is a problem with Flaxseed oil contains a-linolenic acid (ALA), which the body can break down into an omega-3 fatty acid. Though tiny, they are rich in the omega-3 fatty acid ALA, lignans and fiber, all of which have been shown to have many potential health . Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. J Clin Endocrinol Metab 2002;87:1527-32.. View abstract. Milder IE, Feskens EJ, Arts IC, et al. The effectiveness of your oral contraceptives or hormonal therapy may also be affected by flaxseed meal consumption. The Problem With Flaxseed And Thyroid Function. Flaxseed oil might lower blood pressure. Anaphylaxis caused by linseed (flaxseed) intake. All rights reserved. View abstract. Wang C, Makela T, Hase T, et al. Anticoagulant and anti-platelet drugs, herbs and supplements. This content does not have an Arabic version. Int J Cancer 2006;119:925-31. Chen J, Hui E, Ip T, Thompson LU. You should stop consuming these seeds, if you notice any itching, swelling, redness, or hives. The use of flax seeds or flaxseed oil may result in lowered blood sugar. Obstet Gynecol 2002;100:495-504.. View abstract. Can increase. Mount Sinai cautions against combining flaxseed oil, diabetes and certain medications that lower blood sugar. Flax seed oil is in the drug class herbal products. Thompson LU, Chen JM, Li T, et al. Monitor your blood pressure closely. Clark WF, Parbtani A, Huff MW, et al. Flaxseed might also be helpful for managing diabetes and lowering the risk of heart disease. Daru. Herb-Drug Interactions Milk thistle is an inhibitor . Often youll need to take flaxseed oil a few hours before administering medications to make sure your body absorbs them properly. Adlercreutz H, Heikkinen R, Woods M, et al. View abstract. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. 1995;49(3):169-178. But before you take some, you decide to do some research on the interactions it may have with some of the medications you are currently taking. Int J Cancer 2004;111:444-50.. View abstract. Asia Pac J Clin Nutr. A single copy of these materials may be reprinted for noncommercial personal use only. It is created by eHealthMe based on reports of 30 people who take . Ultimately, if flaxseed is to blame, an upped dosage of levothyroxine medication is probably needed going further. Int J Prev Med. Exp Biol Med (Maywood) 2007;232:1071-80. Flaxseed is an herbal supplement used to treat constipation (chronic), enlarged prostate (oil), cancer (prevention), diabetes, diverticulitis, inflammation of the small intestine and/or the stomach, high cholesterol, irritable bowel syndrome, menopausal symptoms, myocardial infarction prevention (oil), skin inflammation, and systemic lupus Is Flaxseed Good for Thyroid? View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Pan A, Sun J, Chen Y, et al. View abstract. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. View abstract. View abstract. Bloedon LT, Balikai S, Chittams J, et al. Consult with a licensed healthcare professional before using any herbal/health supplement. A deficiency of vitamin B12 can cause permanent neurological and nerve damage as well as mood changes and decreased energy. Polypodium Leucotomos - Inotersen. Zeleniuch-Jacquotte A, Lundin E, Micheli A, et al. You may opt-out of email communications at any time by clicking on Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. J Am Coll Nutr 2008;27:65-74. Do not use this product without medical advice if you are breast-feeding a baby. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. How fast does psyllium work? However, it requires a steady dose of essential nutrients, which must come from food or supplements, in order to function at its best. It may take 1 to 3 days before this medication starts working. Flaxseed consumption may reduce blood pressure: A systematic review and meta-analysis of controlled trials. Dietary flaxseed independently lowers circulating cholesterol and lowers it beyond the effects of cholesterol-lowering medications alone in patients with peripheral artery disease. Saarinen NM, Power K, Chen J, Thompson LU. Flaxseed and flaxseed oil. Mayo Clinic does not endorse any of the third party products and services advertised. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Natural Medicines. 5 Science-Based Benefits of 5-HTP (Plus Dosage and Side Effects), The 15 Best Vitamin Brands of 2023: A Dietitians Picks, Red Raspberry Leaf Tea: Pregnancy, Benefits, and Side Effects. These medications may cause some risk when taken together. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Int J Food Sci Nutr. Accessed Sept. 27, 2017. Albuterol Inhalation (Ventolin) Amoxicillin (Amoxil) Azithromycin (Zithromax) CoQ10 (Coenzyme Q-10) Ibuprofen (Advil) Levothyroxine (Synthroid) Lexapro (Escitalopram) Lipitor (Atorvastatin) . A high dose of flaxseed reduces the production of pro-inflammatory eicosanoids such as thrombozane A2 and other lipids mediators like platetet-activating factor (PAF). 2019;10:218. View abstract. High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. are using cholesterol-lowering drugs. Cornish SM, Chilibeck PD, Paus-Jennsen L, et al. National Center for Complementary and Integrative Health. View abstract. Although not all side effects are known, flax is thought to be likely safe for most people when taken by mouth. View abstract. The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenografts is attributed to both its lignan and oil components. Ramon JM, Bou R, Romea S, et al. Flaxseeds are high in potassium. View abstract. Brooks JD, Ward WE, Lewis JE, et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Because flaxseed oil might decrease blood clotting, stop using flaxseed oil two weeks before having elective surgery. Appetite 2012;58:490-5. View abstract. List Flaxseed side effects by likelihood and severity. The omega-3 supplement may increase your fasting blood sugar levels and decrease the effectiveness of your diabetes medication. However, research has shown that flax may not be effective in treating this condition. Answer: Atorvastatin (Lipitor), rosuvastatin (Crestor), and other cholesterol-lowering statin drugs can be affected by taking supplements and can affect your ability to absorb certain vitamins and minerals. No related drugs found for this medication. 2015 Apr;145(4):758-65. View abstract. Adlercreutz H. Diet, breast cancer, and sex hormone metabolism. If you need surgery, dental work, or a medical procedure, stop taking flax at least 2 weeks ahead of time. February 23, 2023. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. J Natl Cancer Inst 2007;99:475-86. Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. The Mayo Clinic warns that using flaxseed oil with this blood thinner, or any other anticoagulant, may increase your risk of bleeding. Br J Nutr 1993;69:443-53. Barbiturate medicines that are prescribed for treating insomnia, controlling anxiety, or treating seizures may interfere with the effectiveness of the birth control pill. Suzuki R, Rylander-Rudqvist T, Saji S, et al. Please contact your doctor or pharmacist. Flaxseed attenuates the tumor growth stimulating effect of soy protein in ovariectomized athymic mice with MCF-7 human breast cancer xenografts. Clin Nutr ESPEN. Generic name: flax (FLACKS) There are three primary types of omega-3s, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). The grapefruit causes larger amounts of the medication to stay in your body for a longer period of time, explains Mayo Clinic nutritionist Katherine Zeratsky 3. View abstract. Potent antihypertensive action of dietary flaxseed in hypertensive patients. This article explores 6 potential health benefits of flaxseed oil, plus how to use it. View abstract. February 24, 2023. Flaxseed interacts with 583 drugs . Am J Clin Nutr 1994;60:122-8. However, when taken in large amounts and with too little water, flaxseed can cause: Avoid use of flaxseed and flaxseed oil during pregnancy. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Yes: Flaxseed may interact with acetaminophen, certain antibiotics, estrogens, furosemide, Ketoprofen, diabetes medication, anticoagulants & Metoprolo. Cancer Causes Control 2000;11:679-85. View abstract. Coulman KD, Liu Z, Michaelides J, et al. Am J Clin Nutr 1999;69:549-55. (n.d.). Call your doctor if the condition you are treating with flax does not improve, or if it gets worse while using this product. Anticancer Res 1998;18:1405-8. Flax is the seed of a plant called Linum usitatissimum, and is also known as Flax Seed, Alasi, Aliviraaii, Brown Flaxseed, Brown-Seeded Flax, Echter Lein, Flachssamen, Flax Hull, Flax Lignans, Gemeiner Flachs, Graine de Lin, Kattan, Keten, Leinsamen, Lignans, Lin, Olagineux, Lin Textile, Linaza, Lini Semen, Linho, Lino, Linseed, Lint Bells, While choosing an Omega 3 supplement, it is . National Institutes of Health: Office of Dietary Supplements: "Omega-3 Fatty Acids", Journal of Food Science and Technology: "Flax and Flaxseed Oil: An Ancient Medicine & Modern Functional Food", Harvard T.H. Do not use different formulations of flax (such as tablets, liquids, and others) at the same time, unless specifically directed to do so by a health care professional. For many, the benefits of flax seeds and flaxseed oil may outweigh the risks of using the product. View abstract. Cats require certain vitamins, minerals, and . Rickard SE, Yuan YV, Thompson LU. Clin Nutr. Flaxseed can be used whole or crushed, or in a powder form as meal or flour. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Salmon, wild - bone loss, joint pain. There are 10 disease interactions with Cymbalta (duloxetine) which include: Liver Disease Renal Disease Depression Diabetes Glaucoma Hypertension Hyponatremia Mania Seizures Urinary Tract Obstruction Is it safe to eat raw flaxseed during pregnancy? Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition. Cancer Causes Control 2008;19:259-72. Do not use extra flax to make up the missed dose. Flaxseed consumption reduces blood pressure in patients with hypertension by altering circulating oxylipins via an a-linolenic acid-induced inhibition of soluble epoxide hydrolase. Explore (NY) 2021. Am J Clin Nutr 2004;80:204-16. Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. There is conflicting research about whether ALA found in flax seeds and flaxseed oil actually causes tumors from prostate cancer to be more aggressive. Flax should not be used in place of medication prescribed for you by your doctor. Ibrgger S, Kristensen M, Mikkelsen MS, Astrup A. Flaxseed dietary fiber supplements for suppression of appetite and food intake. Natural Medicines. Walnuts - bone loss, joint pain. Not all possible interactions are listed in this product guide. Talk to your primary care provider or pharmacist to discuss flaxseed oil drug interactions. View abstract. Fish, walnuts, chia seeds and flaxseed oil are excellent sources of omega-3 fats. Wong H, Chahal N, Manlhiot C, Niedra E, McCrindle BW. In addition, 1.3 percent of patients who were unaware they had moderate kidney impairment took flaxseed oil, which translates to 167,500 Americans. View abstract. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. View abstract. Common interactions include back pain among females and flushing among males. Other uses not proven with research have included enlarged prostate, heart disease, constipation, high blood pressure, irritable bowel syndrome, menopausal symptoms, weight loss, diverticulitis, attention deficit-hyperactivity disorder (ADHD), cancer (prostate, breast, lung, endometrial), and others. However, because antibiotics kill these bacteria, lignans might not be formed as usual. View abstract. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Systemic lupus erythematosus (SLE) nephritis, Constipation. No, it's not always safe to take flaxseed oil with other medications. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Phytother Res 2021;35(7):3781-3791. Summary: Drug interactions are reported among people who take Flaxseed and Anastrozole. 2015 Apr;145(4):749-57. Do not take flax without medical advice if you are using any of the following medications: any medications for diabetes or high blood pressure; This list is not complete. Hemodial Int. Wu H, Pan A, Yu Z, et al. Yes, several popular herbal supplements can impact the effectiveness of apixaban (Eliquis), rivaroxaban (Xarelto), betrixaban (Bevyxxa), and other anticoagulant drugs (blood-thinners) classified as direct factor Xa inhibitors. Read more: 17 Reasons Why You Probably Need More Omega-3s in Your Diet. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Advertising and sponsorship opportunities. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Hypertension. Nutr Rev. or aspirin. Flaxseed oil may cause complications with women who are pregnant because of its ability to affect hormones. Chen J, Power KA, Mann J, et al. View abstract. 016 Sep 1;21:70. Flaxseed oil doesnt contain fiber like flax seeds, however. These blood-thinners are broken down in the body by the liver enzyme CYP3A4. J Am Coll Nutr 1993;12:501-4. This might alter the effects of flaxseed. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. Maternal flaxseed diet during pregnancy or lactation increases female rat offspring's susceptibility to carcinogen-induced mammary tumorigenesis. Clin Rheumatol. Oncology Nutrition advises that you should discuss the use of flax seeds with your doctor and avoid the use of flaxseed oil altogether because it provides no benefit to those with prostate cancer. Nutr Cancer 1997;27:26-30. J Med Food. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. ", Kardiologia Polska: "Linseed Oil Increases HDL3 Cholesterol and Decreases Blood Pressure in Patients Diagnosed With Mild Hypercholesterolaemia", Phytotherapy Research: "A Comparison Between the Effects of Flaxseed Oil and Fish Oil Supplementation on Cardiovascular Health in Type 2 Diabetic Patients With Coronary Heart Disease: A Randomized, Double-Blinded, Placebo-Controlled Trial", U.S. National Library of Medicine: "Warfarin". Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. This means that flaxseed can help improve digestion and lower cholesterol levels, while flaxseed oil does not have these effects. Nordstrom DC, Honkanen VE, Nasu Y, et al. Rodriguez-Leyva D, Rodriguez-Portelles A, Weighell W, Guzman R, Maddaford TG, Pierce GN. Flaxseed: a potential treatment for lupus nephritis. Hedelin M, Lof M, Olsson M, et al. Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Certain herbal supplements, such as St. John's wort, may decrease blood levels of some statin drugs, and when taken with atorvastatin, may . Dietary fat and prostate cancer: current status. Limited animal studies have found that flaxseed and flaxseed oil do not interfere with actions of tamoxifen or trastuzumab (medications used for breast cancer treatment) and may even enhance their effectiveness. are using nonsteroidal anti-inflammatory drugs. Here are 9 teas that help treat stomach problems. These types of drugs, herbs and supplements reduce blood clotting. The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency. Flaxseed may interfere with the absorption of some medications. Vomiting and nausea may also be signs of an allergy. This is not a complete list of side effects and others may occur. Though flaxseed oil benefits your blood pressure, if you take blood pressure medication and supplement your diet regularly with flaxseed oil, the combination may lower your blood pressure too much.